MAGEL2 IS REQUIRED FOR LEPTIN-MEDIATED DEPOLARIZATION OF POMC NEURONS IN THE HYPOTHALAMIC ARCUATE NUCLEUS IN MICE.

Magel2 is required for leptin-mediated depolarization of POMC neurons in the hypothalamic arcuate nucleus in mice.

Prader-Willi Syndrome is the most common syndromic form of human obesity and is caused by the loss of function of several genes, including MAGEL2.Mice lacking Magel2 display increased weight gain with excess adiposity and other defects suggestive of hypothalamic deficiency.We demonstrate Magel2-null mice are insensitive to the anorexic effect of pe

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Research on the Calculation Method for the Load Distribution of the Dual-Input Counter-Rotating Transmission System

In order to solve the problem of an uneven load distribution in a double-input and double-output gearbox, based on the small-displacement Jacobi spin theory and considering the manufacturing and assembly errors of the gearbox, a Jacobi spin analysis model of the gearbox was established.In order to improve the accuracy of the three-dimensional toler

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Four Most Pathogenic Superfamilies of Insect Pests of Suborder Sternorrhyncha: Invisible Superplunderers of Plant Vitality

Sternorrhyncha representatives are serious pests kitchen knife set of agriculture and forestry all over the world, primarily causing damage to woody plants.Sternorrhyncha members are vectors for the transfer of a large number of viral diseases, and subsequently, the host plant weakens.Additionally, many are inherent in the release of honeydew, on w

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